Tag Archives: NTRK1 gene

TPM3-NTRK1, an actin targeted kinase?

Tropomyosins bind to the cytoskeleton protein actin. They also modulate how other actin binding proteins bind to actin. Nemaline myopathy and Rod myopathy are diseases caused by variations in the TPM3 gene. Several splice variants of tropomyosin are coded for

SQSTM1-NTRK1, a kinase gets fused with a garbage disposal protein

The SQSTM1 gene product, p62, is a scaffold protein involved in protein turnover and signaling. p62 is commonly found in dense protein bodies in eukaryotic cells. In autophagy, p62 (the protein) shuttles ubiquitnated proteins to the autophagosome for degradation (Ciuffa