Tag Archives: LMNA gene

LMNA-NTRK1, weaving kinase domains into a fabric

Lamins A and C are alternatively spliced products of the LMNA gene. Lamins are considered nuclear intermediate filaments. Lamins are components of the nuclear lamina. The nuclear lamina lines the nucleoplasmic side of the nuclear membrane. Diseases caused by variations

Entrectinib Sensitivity Associated With a Novel LMNA-NTRK1 Gene Fusion

The following is a summary of a report that inspired the reference on the LMNA-NTRK1 fusion. Sartore-Bianchi and coworkers who mapped the location of this carcinogenic fusion protein. Things to note in this report:  1. The authors demonstrated phosphorylation of enzymes