Tag Archives: Entrectinib

SCYL3-NTRK1, HEAT repeats with an active kinase

An exciting and perplexing new TrkA fusion: SCYL3-NTRK1. Yes, we have yet another chromosome 1 intra-chromosome rearrangement with NTRK1. This time it is with a rather poorly understood protein whose gene name is SCYL3 and protein name is PACE1 (Protein-associating

Entrectinib Sensitivity Associated With a Novel LMNA-NTRK1 Gene Fusion

The following is a summary of a report that inspired the reference on the LMNA-NTRK1 fusion. Sartore-Bianchi and coworkers who mapped the location of this carcinogenic fusion protein. Things to note in this report:  1. The authors demonstrated phosphorylation of enzymes