Category Archives: TPM3-NTRK1

Identification of NTRK fusions in pediatric mesenchymal tumors

Breaking news Dean Pavlick  of Foundation Medicine, Inc. and coworkers profiled 2,031 advanced cancers from pediatric patients (< 21 years) with the goal of identifying NTRK fusions. The role of one NTRK gene rearrangement, ETV6-NTRK3, was mentioned in adult mammary analog

TPM3-NTRK1, an actin targeted kinase?

Tropomyosins bind to the cytoskeleton protein actin. They also modulate how other actin binding proteins bind to actin. Nemaline myopathy and Rod myopathy are diseases caused by variations in the TPM3 gene. Several splice variants of tropomyosin are coded for