Category Archives: SQSTM1-NTRK1

Identification of NTRK fusions in pediatric mesenchymal tumors

Breaking news Dean Pavlick  of Foundation Medicine, Inc. and coworkers profiled 2,031 advanced cancers from pediatric patients (< 21 years) with the goal of identifying NTRK fusions. The role of one NTRK gene rearrangement, ETV6-NTRK3, was mentioned in adult mammary analog

SQSTM1-NTRK1, a kinase gets fused with a garbage disposal protein

The SQSTM1 gene product, p62, is a scaffold protein involved in protein turnover and signaling. p62 is commonly found in dense protein bodies in eukaryotic cells. In autophagy, p62 (the protein) shuttles ubiquitnated proteins to the autophagosome for degradation (Ciuffa