Category Archives: NTrkA

NFASC-NTRK1, a kinase fused to a glue protein

Neurofascin is a cell adhesion protein that guides neurons. In the wild type protein, the “glue-like” self ssociations occur outside the neuron.  This is not always the case when the neurofascin gene, NFASC, is fused to the TrkA gene, NTRK1.  NFASC-NTRK1 was

Entrectinib Sensitivity Associated With a Novel LMNA-NTRK1 Gene Fusion

The following is a summary of a report that inspired the reference on the LMNA-NTRK1 fusion. Sartore-Bianchi and coworkers who mapped the location of this carcinogenic fusion protein. Things to note in this report:  1. The authors demonstrated phosphorylation of enzymes