Category Archives: NTRK trial

A brief history of NTRK fusions

NTRK fusions (Tropomyosin related kinase fusion proteins) were discovered thirty years ago in search for colon carcinoma associated oncogenes (Martin-Zanca 1986). In those days, fusion proteins were called chimeras, after a Greek mythological monster.  The syntax in most common usage

QKI-NTRK2, quaking with a kinase

The QKI-NTRK2 fusion was mentioned in a report of somatic mutations in pilocytic astrocytoma, the most common childhood brain tumor (Jones 2013). The protein quaking encoded by the QKI gene is an RNA-binding protein. The many splice variations of quaking are making

TPM3-NTRK1, an actin targeted kinase?

Tropomyosins bind to the cytoskeleton protein actin. They also modulate how other actin binding proteins bind to actin. Nemaline myopathy and Rod myopathy are diseases caused by variations in the TPM3 gene. Several splice variants of tropomyosin are coded for