Category Archives: NFASC-NTRK1

SCYL3-NTRK1, HEAT repeats with an active kinase

An exciting and perplexing new TrkA fusion: SCYL3-NTRK1. Yes, we have yet another chromosome 1 intra-chromosome rearrangement with NTRK1. This time it is with a rather poorly understood protein whose gene name is SCYL3 and protein name is PACE1 (Protein-associating

A brief history of NTRK fusions

NTRK fusions (Tropomyosin related kinase fusion proteins) were discovered thirty years ago in search for colon carcinoma associated oncogenes (Martin-Zanca 1986). In those days, fusion proteins were called chimeras, after a Greek mythological monster.  The syntax in most common usage

NFASC-NTRK1, a kinase fused to a glue protein

Neurofascin is a cell adhesion protein that guides neurons. In the wild type protein, the “glue-like” self ssociations occur outside the neuron.  This is not always the case when the neurofascin gene, NFASC, is fused to the TrkA gene, NTRK1.  NFASC-NTRK1 was