Category Archives: ETV6-NTRK3

Identification of NTRK fusions in pediatric mesenchymal tumors

Breaking news Dean Pavlick  of Foundation Medicine, Inc. and coworkers profiled 2,031 advanced cancers from pediatric patients (< 21 years) with the goal of identifying NTRK fusions. The role of one NTRK gene rearrangement, ETV6-NTRK3, was mentioned in adult mammary analog

ETV6-NTRK3, produces a kinase polymer from a transcription factor

The ETV6-NTRK3 fusion is diagnostic for both secretory carcinoma in breast, and mammary analog secretory carcinoma or MASC. The ETV6 gene codes for a transcription factor in the ETS (E26 transformation specific) family. The protein product of this gene is