Monthly Archives: April 2017

A brief history of NTRK fusions

NTRK fusions (Tropomyosin related kinase fusion proteins) were discovered thirty years ago in search for colon carcinoma associated oncogenes (Martin-Zanca 1986). In those days, fusion proteins were called chimeras, after a Greek mythological monster.  The syntax in most common usage

MYO5A-NTRK3, a motor fused to a kinase

Have motor, will travel. Lu Wang of  Memorial Sloan Kettering Cancer Center and a very large group of coworkers published an extremely interesting report of a MYO5A-NTRK3 gene rearrangement of the long arm of chromosome 5 in a childhood melanocytic

Identification of NTRK fusions in pediatric mesenchymal tumors

Breaking news Dean Pavlick  of Foundation Medicine, Inc. and coworkers profiled 2,031 advanced cancers from pediatric patients (< 21 years) with the goal of identifying NTRK fusions. The role of one NTRK gene rearrangement, ETV6-NTRK3, was mentioned in adult mammary analog